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Product Information
Pantoley
Information reviewed 2 November 2026. Sources are listed at the end of this section.
Overview
Pantoley contains pantoprazole, a proton pump inhibitor that reduces the production of stomach acid. Each tablet contains 40 mg of pantoprazole as pantoprazole sodium sesquihydrate, in a gastro-resistant (enteric-coated, delayed-release) tablet that releases the medicine in the intestine. Pantoley is manufactured by Hi-Med Pharmaceuticals, Lahore.
Other ingredients (DRAP-hosted SmPC): tablet core: mannitol, crospovidone, anhydrous sodium carbonate, hydroxypropylcellulose, calcium stearate; coating: hypromellose, yellow iron oxide (E172), methacrylic acid-ethyl acrylate copolymer (1:1), triethyl citrate. Less than 1 mmol (23 mg) sodium per tablet. Swallow whole; do not chew or crush.
Indications & Uses
Pantoley is a prescription medicine. Its approved indications are set out in its DRAP-approved product information. In line with DRAP's rules on medicine advertising, indications are shared with healthcare professionals on request.
Contraindications, precautions and storage follow the DRAP-hosted SmPC for Pantoley. Side effects and interactions are summarised from the UK SmPC for pantoprazole 40 mg gastro-resistant tablets (same substance, strength and form).
Common (may affect up to 1 in 10 people)
Benign polyps in the stomach (fundic gland polyps)
Uncommon (may affect up to 1 in 100 people)
Headache, dizziness, sleep problems
Diarrhoea, nausea or vomiting, bloating, constipation, dry mouth, stomach pain
Raised liver enzymes
Rash, itching
Fracture of the hip, wrist or spine
Weakness, tiredness, feeling unwell
Serious effects reported (rare, very rare or frequency not known)
Severe allergic reactions, including anaphylactic shock
Not everyone gets side effects. Tell your doctor or pharmacist about any side effect, including ones not listed here.
Warnings & Precautions
Do not use
If allergic to pantoprazole, other substituted benzimidazoles or any other ingredient
Take special care
Not recommended for children under 12 years
Severe liver impairment: liver enzymes should be monitored
Warning symptoms such as unintended weight loss, repeated vomiting, difficulty swallowing, vomiting blood, anaemia or black stools need prompt medical review
Long-term use: possible low vitamin B12 or magnesium and a small increase in fracture risk; regular review is needed
Slightly higher risk of some bacterial gut infections
Stop at least 5 days before a chromogranin A blood test
Pregnancy and breastfeeding
Avoid in pregnancy as a precaution
Pantoprazole passes into breast milk
Interactions
Atazanavir and similar HIV medicines that need stomach acid for absorptionnot recommended
Ketoconazole, itraconazole, posaconazole, erlotinibabsorption may be reduced
High-dose methotrexatelevels may rise
Warfarin and phenprocoumonmonitor clotting (INR)
Fluvoxamine may raise, and rifampicin or St John's wort may lower, pantoprazole levels
Tell your doctor or pharmacist about all medicines and supplements you take.
Storage
Do not store above 30 °C. Store in the original package (DRAP-hosted SmPC; shelf life 2 years). Keep out of the reach of children.
